I wouldn't mind trying Infamous if they'd port it to the 360, which they won't. I played Prototype, which is similar, and I really liked it. The game was a lot of fun if for no other reason than grabbing random people down on the street, parkour-running to the top of a skyscraper, then either throwing them away to watch them hilariously fly off into the sunset in WTFville, or eating them and turning into them to run around on street level for a little while. Fun game.
I guess I was the only person in the world disappointed by Mass Effect 2 and its watered-down plot and dumbed-down RPG mechanics. I mean, it had its fun moments, but it was just lacking.